What is the catalog number for BCL-6 corepressor Antibody / BCOR?

The catalog number for BCL-6 corepressor Antibody / BCOR is V5339SAF-100UG.

What sizes are available for BCL-6 corepressor Antibody / BCOR?

BCL-6 corepressor Antibody / BCOR is available in the following size(s): 100 µg.

Is BCL-6 corepressor Antibody / BCOR in stock?

BCL-6 corepressor Antibody / BCOR is currently made to order / not held in immediate stock. Contact us for lead time.

BCL-6 corepressor Antibody / BCOR

Bcl-6, a transcriptional repressor, can promote or inhibit apoptosis depending on the cell type and also plays an important role in normal immune responses. Bcl-6 negatively regulates NFkB expression, thereby inhibiting NFkB-mediated cellular functions and is frequently found to be deregulated in non-Hodgkin s lymphoma. BCoR (Bcl-6 corepressor) is a 1,755 amino acid protein that associates with histone deacetylases (HDACs) to transcriptionally repress Bcl-6. With ubiquitous expression, BCoR is localized to the nucleus where it interacts with other proteins through its three ANK repeat domains. Mutations in the gene encoding BCoR result in microphthalmia with associated anomalies 2, also known as anophthalmia, which is characterized by variable features, such as renal aplasia, mental retardation, hyospadias, microencephaly and cryptorchidism. There are four isoforms of BCoR which are produced as a result of alternative splicing events.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

Q6W2J9

Host

Mouse

Reactivity

Human

Immunogen

A recombinant partial protein sequence (within amino acids 100-400) from the human protein was used as the immunogen for the BCL-6 corepressor antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

BCOR/2372

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the BCL-6 corepressor antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This BCL-6 corepressor antibody is available for research use only.

Storage Conditions

Aliquot the BCL-6 corepressor antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the BCL-6 corepressor antibody should be determined by the researcher.

Location

Nucleus

Image Legend

Analysis of a HuProt (TM) microarray containing more than 19,000 full-length human proteins using BCL-6 corepressor antibody (clone BCOR/2372) . Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.