TIMP1 Antibody / Tissue Inhibitor of Metalloproteinase 1
Selected Variant
V5329SAF-100UG
Size: 100 µg
TIMP-1, TIMP-2, TIMP-3 and TIMP-4 (for tissue inhibitor of metalloproteinases -1, -2, -3 and -4) complex with metalloproteinases such as collagenases, gelatinases and stromelysins, resulting in irreversible inactivation of the metalloproteinase. TIMP-1 is identical to EPA (erythroid-potentiation activity) . PTH has been shown to be a regulator of TIMP-2 in osteoblastic cells. TIMP-3 may be involved in regulating trophoblastic invasion of the uterus as well as in regulating remodeling of the extracellular matrix during the folding of epithelia, and in the formation, branching and expansion of epithelial tubes. TIMP-4 is most highly expressed in heart tissues. Studies have demonstrated that TIMP1 is useful as a biomarker for early detection of colorectal cancer, outperforming CEA. Additionally, TIMP1 studies have demonstrated its role in CRC tumorigenesis, as well as observing its overexpression in metastatic lymph nodes.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA: 2-4 mg/mL for coating (order BSA-free format), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01033
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human TIMP1 protein fragment (within amino acids 1-200) was used as the immunogen for the TIMP1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
TIMP1/2605
Applications
ELISA, IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the TIMP1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TIMP1 antibody is available for research use only.
Storage Conditions
Aliquot the TIMP1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the TIMP1 antibody should be determined by the researcher.
Location
Cytoplasm, Secreted
Image Legend
Price
Documents
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