FOXP3 Antibody / Forkhead box protein P3 / Scurfin
The FOX family of transcription factors is a large group of proteins that share a common DNA binding domain termed a winged-helix or forkhead domain. During early development, FOXP1 and FOXP2 are expressed abundantly in the lung, with lower levels of expression in neural, intestinal and cardiovascular tissues, where they act as transcription repressors. FOXP1 is widely expressed in adult tissues, while neoplastic cells often exhibit a dramatic change in expression level or localization of FOXP1. Mutations in FOXP3 gene cause IPEX, a fatal, X-linked inherited disorder characterized by immune dysregulation. The FOXP3 protein is essential for normal immune homeostasis. Specifically, FOXP3 represses transcription through a DNA binding forkhead domain, thereby regulating T cell activation.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q9BZS1
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 300-431) from the human protein was used as the immunogen for the FOXP3 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
FOXP3/7990R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the FOXP3 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This FOXP3 antibody is available for research use only.
Storage Conditions
Aliquot the FOXP3 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the FOXP3 antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Frequently Asked Questions
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