CD274 Antibody / PD-L1 / B7-H1
PD-L1/CD274 is a checkpoint regulator in immune cells, it is expressed on immune or non-hematopoietic cells. Expression of the protein is seen during pregnancy where it has a role in suppressing the immune system. PD-L1 induces an inhibitory signal in activated T-cells and promotes T-cell apoptosis. It is overexpressed in a number of different cancers where it is believed to play a significant role in the cancer s ability to evade the immune system.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q9NZQ7
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 190-290) from the human protein was used as the immunogen for the CD274 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RPDL1/8825
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD274 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD274 antibody is available for research use only.
Storage Conditions
Aliquot the CD274 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD274 antibody should be determined by the researcher.
Location
Cell Surface, Cytoplasm
Image Legend
SDS-PAGE analysis of purified, BSA-free CD274 antibody (clone rPDL1/8825) as confirmation of integrity and purity.
Frequently Asked Questions
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