Tyrosinase-Related Protein-1 Antibody / TYRP1
It reacts with a 75kDa melanocyte-specific gene product, identified as Tyrosinase-related protein-1 (TRP-1) . It is involved in melanin synthesis. TRP1 is present on the melanosomal membranes of melanoma, normal melanocytes and nevi. Recent evidence suggests that TRP-1 is involved in maintaining stability of tyrosinase protein and modulating its catalytic activity. TRP-1 is also involved in maintenance of melanosome ultrastructure and affects melanocyte proliferation and cell death.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P17643
Host
Rabbit
Reactivity
Human
Immunogen
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
TYRP1/8313R
Type
Recombinant
Applications
IHC-P
Purity
Protein A affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Tyrosinase-Related Protein-1 antibody is available for research use only.
Storage Conditions
Aliquot the Tyrosinase-Related Protein-1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Tyrosinase-Related Protein-1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Frequently Asked Questions
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