NTRK2 Antibody / TrkB / Neurotrophic tyrosine kinase receptor type 2
Selected Variant
V5270SAF-100UG
Size: 100 µg
The Trk proto-oncogene encodes a tyrosine protein kinase, Trk A, also designated Trk gp140, that serves as a receptor for certain neurotrophic factors including nerve growth factor (NGF) and neurotrophin-3 (NT-3) . Trk B is a tyrosine kinase gene highly related to Trk A. The brain-derived neurotrophic factor (BDNF) and NT-3, but not NGF, can induce rapid phosphorylation on tyrosine of Trk B gp145, one of the receptors encoded by NTRK2, although BDNF elicits a response at least two orders of magnitude greater than NT-3. Thus it appears that Trk B gp145 may represent a neurotrophic receptor for BDNF and NT-3. The third member of the Trk family of tyrosine kinases, Trk C, encodes a protein designated Trk C gp145 that is preferentially expressed in brain tissue, is equally related to Trk A and Trk B and is a functional receptor for NT-3.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q16620
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 250-450) from the human protein was used as the immunogen for the NTRK2 antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
NTRK2/4671
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the NTRK2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This NTRK2 antibody is available for research use only.
Storage Conditions
Aliquot the NTRK2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the NTRK2 antibody should be determined by the researcher.
Location
Cell surface, cytoplasm
Image Legend
Price
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