P-glycoprotein Antibody / MDR1 / ABCB1
Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR) . MDR proteins (Mdrs) are members of a highly conserved superfamily of ATP-binding cassette transport proteins. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. The Mdr-1 gene is known as ABCB1 and is located on human chromosome 7q21.12. The mouse homolog of Mdr-1 is known as Mdr-3. Interestingly, a murine protein by the name of Mdr-1 exists and is encoded by the murine Abcb1b gene, but it is not homologous with human Mdr-1.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P08183
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 500-700) from the human protein was used as the immunogen for the P-glycoprotein antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
MDR1/8962R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the P-glycoprotein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This P-glycoprotein antibody is available for research use only.
Storage Conditions
Aliquot the P-glycoprotein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the P-glycoprotein antibody should be determined by the researcher.
Location
Membrane
Image Legend
Frequently Asked Questions
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