Glycophorin A Antibody / GYPA
Recognizes a sialoglycoprotein of 39kDa, identified as glycophorin A (GPA) . It is present on red blood cells (RBC) and erythroid precursor cells. It has been shown that glycophorin acts as the receptor for Sandei virus and parvovirus. Glycophorins A (GPA) and B (GPB), which are single, trans-membrane sialoglycoproteins. GPA is the carrier of blood group M and N specificities, while GPB accounts for S and U specificities. GPA and GPB provide the cells with a large mucin like surface and it has been suggested this provides a barrier to cell fusion, so minimizing aggregation between red blood cells in the circulation.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P02724
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human glycophorin A protein was used as the immunogen for the Glycophorin A antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG2b κ
Clone
RGYPA/8948
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Glycophorin A antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Glycophorin A antibody is available for research use only.
Storage Conditions
Aliquot the Glycophorin A antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Glycophorin A antibody should be determined by the researcher.
Location
Cytoplasmic, membranous
Image Legend
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