C-Kit Antibody / CD117 / SCFR
This mAb recognizes a protein of 145kDa, identified as CD117/p145kit. It is found on a wide variety of tumor cells including follicular and papillary carcinoma of thyroid, adenocarcinomas from endometrium, lung, ovary, pancreas, and breast as well as malignant melanoma, endodermal sinus tumor, and small cell carcinoma. However, anti-CD117 has been particularly useful in differentiating gastrointestinal stromal tumors from Kaposi s sarcoma, tumors of smooth muscle origin, fibromatosis, and neural tumors of the GI tract. Anti-CD117 is also useful in recognizing myeloblasts in bone marrow biopsy and clot section.
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA: 2-4 µg/mL (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P10721
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the c-Kit antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
C117/8879R
Type
Recombinant
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the c-Kit antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This c-Kit antibody is available for research use only.
Storage Conditions
Aliquot the c-Kit antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the c-Kit antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
Documents
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