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Paired-like homeobox 2B Antibody / PHOX2B

Paired homeobox protein 2B (PHOX2B) is a transcription factor located on chromosome 4p13, which is essential for the formation of autonomic ganglia in the autonomic nervous system. PHOX2B is expressed in neuroblastoma, brain and adrenal glands. PHOX2B deficiency can lead to susceptibility to congenital central hypoventilation syndrome (CCHS) and neuroblastoma type 2 (NBLST2) .

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

Q99453

Host

Rabbit

Reactivity

Human

Immunogen

A recombinant fragment of human protein was used as the immunogen for the Paired-like homeobox 2B antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG κ

Clone

PHOX2B/7792R

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the Paired-like homeobox 2B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Paired-like homeobox 2B antibody is available for research use only.

Storage Conditions

Aliquot the Paired-like homeobox 2B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the Paired-like homeobox 2B antibody should be determined by the researcher.

Location

Nucleus

Image Legend

IHC staining of FFPE human renal cell carcinoma tissue with Paired-like homeobox 2B antibody (clone PHOX2B/7792R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.

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