Forkhead box protein L2 Antibody / FOXL2

FOXL2 is a critical factor essential for ovary differentiation and maintenance, and repression of the genetic program for somatic testis determination. It prevents trans-differentiation of ovary to testis through transcriptional repression of the sertoli cell-promoting gene SOX9. FOXL2 is mainly expressed in ovary, parathyroid gland and sex cord-stromal tumors. FOXL2 is generally used for diagnosis of sex cord-stromal tumors with Inhibin, Calretinin and SF-1.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

P58012

Host

Rabbit

Reactivity

Human

Immunogen

Recombinant full-length human FOXL2 protein was used as the immunogen for the FOXL2 antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG κ

Clone

FOXL2/8362R

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the FOXL2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This FOXL2 antibody is available for research use only.

Storage Conditions

Aliquot the FOXL2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the FOXL2 antibody should be determined by the researcher.

Location

Nucleus

Image Legend

IHC staining of FFPE human parathyroid tissue with Forkhead box protein L2 antibody (clone FOXL2/8362R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.