PDCD1 Antibody / PD-1
PDCD-1 (programmed cell death-1 protein), also designated CD279, is a type I transmembrane receptor and a member of the immunoglobin gene superfamily. It is expressed on activated T-cells, B-cells, and myeloid cells. Anti-PDCD-1 is a marker of angioimmunoblastic lymphoma and suggests a unique cell of origin for this neoplasm. Unlike CD10 and BCL6, PDCD-1 is expressed by few B-cells, so anti-PDCD-1 may be a more specific and useful diagnostic marker in angioimmunoblastic lymphoma. In addition, PDCD-1 expression provides evidence that angioimmunoblastic lymphoma is a neoplasm derived from germinal center-associated T-cells.
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q15116
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment corresponding to the extracellular domain of human PDCD1 protein was used as the immunogen for the PDCD1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
PDCD1/7255R
Type
Recombinant
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the PDCD1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This PDCD1 antibody is available for research use only.
Storage Conditions
Aliquot the PDCD1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the PDCD1 antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Frequently Asked Questions
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