MutS homolog 2 Antibody / MSH2
Mutations in DNA mismatch repair genes are associated with hereditary nonpolyposis colorectal cancer (HNPCC) . Initially, inherited mutations in the MSH2 and MLH1 homologs of the bacterial DNA mismatch repair genes MutS and MutL were found at high frequency in HNPCC and were shown to be associated with microsatellite instability. The demonstration that 10 to 45% of pancreatic, gastric, breast, ovarian and small cell lung cancers also display microsatellite instability has been interpreted to suggest that DNA mismatch repair is not restricted to HNPCC tumors but is a common feature in tumor initiation or progression.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P43246
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 300-500) from the human protein was used as the immunogen for the MutS homolog 2 antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
MSH2/3165
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the MutS homolog 2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MutS homolog 2 antibody is available for research use only.
Storage Conditions
Aliquot the MutS homolog 2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the MutS homolog 2 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
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