Langerin Antibody / CD207
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG). BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Product Specifications
UniProt
Q9UJ71
Host
Mouse
Immunogen
A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the Langerin antibody.
Clonality
Monoclonal
Isotype
IgG
Applications
IHC-P
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Langerin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Langerin antibody is available for research use only.
CAS Number
9007-83-4
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