Langerin Antibody / CD207
Langerhans cells (LCs) are a subset of immature dendritic cells (DCs) that specifically localize in the epidermis and other mucosal epithelia. Epidermal LCs possess strong immuno-stimulatory capacity and play a central role in the initiation and regulation of immune responses. Langerin (CD207) is a Ca2+-dependent, C-type lectin domain containing, type II transmembrane protein that induces epidermal LCs to differentiate into Birbeck granules (BG) . BGs are organelles with superimposing and zippering membranes that influence proper class I type antigen presentation to the circulating T cells. Human spleen, lymph node, thymus, liver, lung and heart express Langerin protein.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
Q9UJ71
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 50-250) from the human protein was used as the immunogen for the Langerin antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
LGRN/7357
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Langerin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Langerin antibody is available for research use only.
Storage Conditions
Aliquot the Langerin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Langerin antibody should be determined by the researcher.
Location
Cell surface, Cytoplasm
Image Legend
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