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Kinesin like protein 6 Antibody / KIF2C / MCAK

Kinesin family member 2c (KIF2C), alternately known as mitotic centromere associated kinesin (MCAK), is a member of the kinesin-like family of proteins. KIF2C is a cytoplasmic and nuclear protein, present throughout the cell cycle. KIF2C associates with the centromere early in prophase, and disassociates after telophase. KIF2C is abundant in thymus and testis, and present at lower levels in small intestine, the mucosal lining of the colon, and placenta. Human KIF2C maps to chromosome 1p34.1.

Product Specifications

CAS Number

9007-83-4

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

Q99661

Host

Mouse

Reactivity

Human

Immunogen

A recombinant partial protein sequence (within amino acids 500-700) from the human protein was used as the immunogen for the Kinesin like protein 6 antibody.

Clonality

Monoclonal

Isotype

IgG1 k

Clone

KIF2C/6520

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

1 mg/ml in 1X PBS; BSA free, sodium azide free

Reconstitution

Aliquot the Kinesin like protein 6 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Kinesin like protein 6 antibody is available for research use only.

Storage Conditions

Aliquot the Kinesin like protein 6 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

1 mg/mL in 1X PBS; BSA free, sodium azide free

Applications Notes

Optimal dilution of the Kinesin like protein 6 antibody should be determined by the researcher.

Location

Cytoplasm, Nucleus

Image Legend

Analysis of a HuProt (TM) microarray containing more than 19,000 full-length human proteins using Kinesin like protein 6 antibody (clone KIF2C/6520) . Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.

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