ERCC1 Antibody
Recognizes a protein of 110kDa, identified as Excision Repair Cross Complementing 1 (ERCC1) . It is a mammalian nucleotide excision repair (NER) enzyme involved in repair of damaged DNA. ERCC1 is a homologous to RAD10 in Saccharomyces cerevisiae, which is required in mitotic intrachromosomal recombination and repair. ERCC1 is required in repair of cisplatin-induced DNA adducts and ultraviolet (UV) -induced DNA damage. High expression of ERCC1 has been linked to tumor progression in a variety of cancers including non-small cell lung cancer (NSCLC), squamous cell carcinoma of the head, ovarian cancer and esophageal cancer.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P07992
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 191-281) from the human protein was used as the immunogen for the ERCC1 antibody.
Clonality
Monoclonal
Isotype
IgG2b κ
Clone
ERCC1/7596
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ERCC1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ERCC1 antibody is available for research use only.
Storage Conditions
Aliquot the ERCC1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ERCC1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Exodus-2, Recombinant, Mouse (Ccl21a, C-C Motif Chemokine 21a, 6Ckine, Beta-chemokine Exodus-2, Small-inducible Cytokine A21a, Thymus-derived Chemotactic Agent 4, TCA4, Scya21, Scya21a) discontinued
