TGF beta Antibody / TGFB
This mAb recognizes TGF beta 1, 2 and 3. Three TGF betas have been identified in mammals. TGF beta 1, TGF beta 2 and TGF beta 3 are each synthesized as precursor proteins that are very similar in that each is cleaved to yield a 112 amino acid polypeptide that remains associated with the latent portion of the molecules. Biologically active TGF beta requires dimerization of the monomers (usually homodimers) and release of the latent peptide portion. Overall, the mature region of the TGF beta 3 protein has approximately 80% identity to the mature region of both TGF beta 1 and TGF beta 2. However, the NH2 terminals or precursor regions of their molecules share only 27% sequence identity. TGF beta s inhibits the growth of epithelial cells and stimulate the growth of mesenchymal cells.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P01137
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 200-390) from the human TGFB1 was used as the immunogen for the TGF beta antibody.
Clonality
Monoclonal
Isotype
IgG
Clone
TGFB/7240
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the TGF beta antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This TGF beta antibody is available for research use only.
Storage Conditions
Aliquot the TGF beta antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the TGF beta antibody should be determined by the researcher.
Location
Cytoplasm, Extracellular (secreted)
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