CD54 Antibody / ICAM-1
Recognizes an 85-115kDa protein (variation with cell type), identified as intercellular adhesion molecule (ICAM-1) . It has 7 potential N-linked glycosylation sites. ICAM-1 is a single chain glycoprotein of Ig supergene family, present on unstimulated endothelial cells (EC) and on a variety of other cell types including activated fibroblasts, EC, macrophages, and lymphocytes. ICAM-1 mediates cell adhesion by binding to integrins CD11a/CD18 (leukocyte adhesion molecule, LFA-1) and to CD11b/CD18 (Mac-1) . This interaction enhances antigen-specific T-cell activation. ICAM-1 also binds to CD43 and to Plasmodium falciparum infected RBCs. ICAM-1 may also be related to progression and metastasis of tumors.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P05362
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment corresponding to the intracellular portion of the human protein was used as the immunogen for the CD54 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
ICAM1/8247R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the CD54 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD54 antibody is available for research use only.
Storage Conditions
Aliquot the CD54 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the CD54 antibody should be determined by the researcher.
Location
Cell Surface
Image Legend
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Ces2h sgRNA CRISPR/Cas9 All-in-One Lentivector set (Rat)
DSG4 sgRNA CRISPR/Cas9 All-in-One Lentivector (Human) (Target 1)
