Calponin 1 Antibody / CNN1
Calponin a 33 kDa polypeptide, is a cytoskeleton-associated actin-binding protein that also interacts tropomyosin and calmodulin. Calponin antibody has been found to be useful as a marker for myoepithelial and basal lamina in differentiating microinvasive from in situ ductal carcinomas of the breast. Calponin antibody may also have applications in malignant myoepithelium and pleomorphic adenoma of salivary gland as well as a useful marker for fine needle aspirates of papillary breast lesions. The antibody has been found in tissue extracts from smooth muscle, but not in fibroblast extracts.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT, Western blot: 2-4 µg/mL
UniProt
P51911
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant fragment corresponding to the human protein was used as the immunogen for the Calponin 1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CNN1/8870R
Type
Recombinant
Applications
IHC-P, WB
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Calponin 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Calponin 1 antibody is available for research use only.
Storage Conditions
Aliquot the Calponin 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Calponin 1 antibody should be determined by the researcher.
Location
Cytoplasm
Image Legend
Western blot testing of human colon tissue lysate with Calponin 1 antibody. Predicted molecular weight ~34 kDa.
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