BRG1 Antibody / SMARCA4
The SWI-SNF complex is involved in the activation of transcription via the remodeling of nucleosome structure in an ATP-dependent manner. Brm (also designated SNF2A) and Brg-1 (also designated SNF2B) are the ATPase subunits of the mammalian SWI/SNF complex. Brm, Brg-1, Ini1 (integrase interactor 1, also designated SNF5), BAF155 (also designated SRG3) and BAF170 are thought to comprise the functional core of the SWI/SNF complex. Addition of Ini1, BAF155 and BAF170 to Brg-1 appears to increase remodeling activity. Other complex subunits are thought to play regulatory roles. hSNF2L and hSNF2H both appear to be homologs of Drosophila ISWI, a Brm related ATPase that is present in chromatin remodeling complexes other than SWI/ SNF, including the NURF (nucleosome remodeling factor) .
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating), Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT
UniProt
P51532
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 200-400) from the human protein was used as the immunogen for the BRG1 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
BRG1/7633R
Type
Recombinant
Applications
ELISA, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the BRG1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This BRG1 antibody is available for research use only.
Storage Conditions
Aliquot the BRG1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/brg1-antibody-smarca4-brg17633r-v4587
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the BRG1 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
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