What is the catalog number for MASPIN Antibody / SERPINB5?

The catalog number for MASPIN Antibody / SERPINB5 is V4579-100UG.

What sizes are available for MASPIN Antibody / SERPINB5?

MASPIN Antibody / SERPINB5 is available in the following size(s): 100 µg.

Is MASPIN Antibody / SERPINB5 in stock?

MASPIN Antibody / SERPINB5 is currently made to order / not held in immediate stock. Contact us for lead time.

MASPIN Antibody / SERPINB5

Maspin is structurally a serine protease inhibitor (serpin) that was initially isolated from normal human mammary epithelial cells. Serpins are a family of proteins that inhibit Chymotrypsin-like serine proteinases. Serpins control activated proteinases and several are involved in the regulation of cell death. Maspin is found in the extracellular matrix and at the plasma membrane. Maspin has been shown to act at the cell surface to block cell motility and inhibit invasion of breast and prostate cancer cells. Maspin is present in normal mammary epithelial cells but is absent in many tumor cell lines, yet no major structural alterations of the Maspin gene have been identified in tumor cells. Similarly, Maspin is expressed in normal prostate cells and downregulated or absent in prostate tumor cells.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 min at RT

UniProt

P36952

Host

Mouse

Reactivity

Human

Immunogen

A recombinant fragment of human protein (within amino acids 1-200) was used as the immunogen for the MASPIN antibody.

Clonality

Monoclonal

Isotype

IgG

Clone

SERPINB5/4978

Applications

WB, IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the MASPIN antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This MASPIN antibody is available for research use only.

Storage Conditions

Aliquot the MASPIN antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the MASPIN antibody should be determined by the researcher.

Location

Secreted, Extracellular space

Image Legend

Analysis of a HuProt (TM) microarray containing more than 19,000 full-length human proteins using MASPIN antibody (clone SERPINB5/4978) . Z- and S- Score: The Z-score represents the strength of a signal that a monoclonal antibody (in combination with a fluorescently-tagged anti-IgG secondary antibody) produces when binding to a particular protein on the HuProt (TM) array. Z-scores are described in units of standard deviations (SD's) above the mean value of all signals generated on that array. If targets on HuProt (TM) are arranged in descending order of the Z-score, the S-score is the difference (also in units of SD's) between the Z-score. S-score therefore represents the relative target specificity of a mAb to its intended target. A mAb is considered to specific to its intended target, if the mAb has an S-score of at least 2.5. For example, if a mAb binds to protein X with a Z-score of 43 and to protein Y with a Z-score of 14, then the S-score for the binding of that mAb to protein X is equal to 29.