Nucleoside diphosphate kinase B Antibody / NDKB / NME2
The nm23 gene, a potential suppressor of metastasis, was originally identified by differential hybridization between two murine melanoma sub-lines, one with a high and the second with a low metastatic capacity. Highly metastatic sub-lines exhibit much lower levels of nm23 than less metastatic cells. Based on sequence analysis, nm23 appears highly related to nucleotide diphosphate kinases (NDP) . In humans, NDP kinases A and B are identical to two isotypes of human nm23 homologs, namely nm23-H1 and H2, respectively. nm23-H2 is identical in sequence to PuF, a transcription factor that binds to nuclease hypersensitive elements at positions 142 to 115 of the human c-Myc promotor.
Product Specifications
Specifications
Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P22392
Host
Mouse
Reactivity
Human
Immunogen
Recombinant full-length human protein was used as the immunogen for the Nucleoside diphosphate kinase B antibody.
Clonality
Monoclonal
Isotype
IgG2 κ
Clone
NME2/6434
Applications
WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the Nucleoside diphosphate kinase B antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Nucleoside diphosphate kinase B antibody is available for research use only.
Storage Conditions
Aliquot the Nucleoside diphosphate kinase B antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Product Datasheet
https://www.nsjbio.com/tds-pdf/nucleoside-diphosphate-kinase-b-antibody-ndkb-nme2-nme26434-v4518
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the Nucleoside diphosphate kinase B antibody should be determined by the researcher.
CAS Number
9007-83-4
Location
Cytoplasm, Nucleus
Image Legend
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