MMP2 Antibody / Matrix metalloproteinase 2
It recognizes a protein of 72kDa, which is identified as MMP2. The matrix metalloproteinases (MMP) are a family of peptidase enzymes responsible for the degradation of extracellular matrix components, including collagen, gelatin, Fibronectin, Laminin and proteoglycan. Transcription of MMP genes is differentially activated by phorbol ester, lipopolysaccharide (LPS) or staphylococcal enterotoxin B (SEB) . MMP catalysis requires both calcium and zinc. MMP-2 (also designated type IV collagenase) cleaves collagen types IV, V, VII and X and gelatin type I. Activation of MMP-2 secretion requires the Ras signaling pathway.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P08253
Host
Mouse
Reactivity
Human
Immunogen
A recombinant human MMP2 protein fragment (within amino acids 557-569) was used as the immunogen for the MMP2 antibody.
Clonality
Monoclonal
Isotype
IgG1
Clone
4D3
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the MMP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This MMP2 antibody is available for research use only.
Storage Conditions
Aliquot the MMP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the MMP2 antibody should be determined by the researcher.
Location
Cytoplasm, Cell Surface
Image Legend
SDS-PAGE analysis of purified, BSA-free MMP2 antibody (clone 4D3) as confirmation of integrity and purity.
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