B-cell maturation protein Antibody / BCMA / CD269 / TNFRSF17
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells) . Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE) .
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q02223
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein fragment (within amino acids 1-184) was used as the immunogen for the B-cell maturation protein antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CD269/8190R
Type
Recombinant
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the B-cell maturation protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This B-cell maturation protein antibody is available for research use only.
Storage Conditions
Aliquot the B-cell maturation protein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the B-cell maturation protein antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Frequently Asked Questions
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