B-cell maturation protein Antibody / BCMA / CD269 / TNFRSF17
The B cell maturation protein (BCMA) is a type I integral membrane protein that belongs to the tumor necrosis factor receptor (TNF-R) superfamily. It is expressed as a 184 amino acid peptide that is expressed only in mature B-lymphocytes and is located on the cis part of the Golgi apparatus. BCMA shares significant homology with TACI (transmembrane activator) within the cysteine-rich domain. TACI has been shown to bind CAML, which induces activation of NFAT (nuclear factor of activated T cells) . Both BCMA and TACI have been shown to bind APRIL and TALL-1, which stimulate B cell proliferation in conjunction with other B-cell activators. When overexpressed, TALL-1 stimulates the development of systemic lupus erythaematosus (SLE) .
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q02223
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant human protein fragment (within amino acids 1-184) was used as the immunogen for the B-cell maturation protein antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CD269/8190R
Type
Recombinant
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the B-cell maturation protein antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This B-cell maturation protein antibody is available for research use only.
Storage Conditions
Aliquot the B-cell maturation protein antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the B-cell maturation protein antibody should be determined by the researcher.
Location
Cell surface
Image Legend
Documents
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Cytokeratin 17 (E3), CF740 conjugate, 0.1mg/mL
Fibronectin (HFN7.1), CF740 conjugate, 0.1mg/mL
TGF-beta (1D11.16.8), CF405S conjugate, 0.1mg/mL
Ep-CAM / CD326 (VU-1D9), CF568 conjugate, 0.1mg/mL
