Polo like kinase 1 Antibody / PLK1
Plk (for polo-like kinase) encodes a serine/threonine kinase that is closely related to polo and CDC5, genes that are required for passage through mitosis in Drosophila and Saccharomyces, respectively. Polo and CDC5 both code for proteins that are involved in regulating the function of the mitotic spindle. Plk protein accumulates in the cell during the S and G2 phases of the cell cycle; Plk protein content and catalytic activity peak at the onset of mitosis, followed by a rapid reduction after mitosis. Plk expression is detectable in mitotically active tissues such as colon and placenta, as well as in tumors of various origins. It has also been suggested that Plk may serve as a marker of cell proliferation.
Product Specifications
CAS Number
9007-83-4
Specifications
ELISA (Order BSA-free format for coating), Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P53350
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human protein (within amino acids 1-200) was used as the immunogen for the Polo like kinase 1 antibody.
Clonality
Monoclonal
Isotype
IgG1 k
Clone
PLK1/7122
Applications
ELISA, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
1 mg/ml in 1X PBS; BSA free, sodium azide free
Reconstitution
Aliquot the Polo like kinase 1 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This Polo like kinase 1 antibody is available for research use only.
Storage Conditions
Aliquot the Polo like kinase 1 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
1 mg/mL in 1X PBS; BSA free, sodium azide free
Applications Notes
Optimal dilution of the Polo like kinase 1 antibody should be determined by the researcher.
Location
Nucleus, Cytoplasm
Image Legend
Documents
Frequently Asked Questions
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