Recombinant GP2 Antibody / Glycoprotein 2 / ZAP75
GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD) . GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
Product Specifications
CAS Number
9000-83-3
Specifications
ELISA: 2-4 mg/mL for coating (order BSA-free format), Western blot: 1-2 µg/mL, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P55259
Host
Mouse
Reactivity
Human
Immunogen
A recombinant fragment of human protein (within amino acids 35-179) was used as the immunogen for the recombinant GP2 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG1 k
Clone
RGP2/8617
Type
Recombinant
Applications
ELISA, WB, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the recombinant GP2 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This recombinant GP2 antibody is available for research use only.
Storage Conditions
Aliquot the recombinant GP2 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the recombinant GP2 antibody should be determined by the researcher.
Location
Cell surface, Secreted, Cytoplasmic
Image Legend
Frequently Asked Questions
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