CD185 Antibody / CXCR5 / BLR1 / MDR15
Burkitt s lymphoma receptor 1 (Blr1), also called CD185, CXCR5 and MDR15, is a lymphocyte specific chemokine receptor expressed at low levels in secondary lymphoid tissues and in defined structures of the cerebellum. The G protein-coupled receptor has significant homology to other chemokine receptors. Stimulation of Blr1 by its ligand, B-lymphocyte chemoattractant (BLC) results in an influx of calcium into the cell and the chemotaxis of the cell. Blr1 is required for B-cell migration into splenic and Peyer s patch follicles. BLC expression in Peyer s patches is highest in germinal centers, where B cells undergo somatic mutation and affinity maturation.
Product Specifications
CAS Number
9000-83-3
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P32302
Host
Rabbit
Reactivity
Human
Immunogen
A recombinant partial protein sequence (within amino acids 1-200) from the human protein was used as the immunogen for the CD185 antibody.
Clonality
Recombinant Monoclonal
Isotype
IgG κ
Clone
CXCR5/8279R
Type
Recombinant
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the CD185 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This CD185 antibody is available for research use only.
Storage Conditions
Aliquot the CD185 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the CD185 antibody should be determined by the researcher.
Location
Cell membrane
Image Legend
Frequently Asked Questions
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