Mammaglobin Antibody

Mammaglobin, 10 kDa, is a cytoplasmic protein, a mammary-specific member of the uteroglobin family. It is related to a family of epithelial secretory proteins that includes prostatein and Clara cell protein.Mammaglobin occurs in about 80% of breast carcinomas. The extend is generally larger than that of GCDFP-15. Up to 15% of nonbreast carcinomas (such as stomach, lung, colon, hepatobiliary, thyroid, ovarian, and urothelial carcinomas) have been reported positive, usually only focally. Mammaglobin is a sensitive and fairly specific marker for breast carcinoma. The panel should also include Gross cystic disease fluid protein-15 and Estrogen receptor alpha.

Product Specifications

CAS Number

9000-83-3

Specifications

Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT

UniProt

Q13296

Host

Rabbit

Reactivity

Human

Immunogen

A recombinant fragment of human Mammaglobin/SCGB2A2 protein was used as the immunogen for the Mammaglobin antibody.

Clonality

Recombinant Monoclonal

Isotype

IgG κ

Clone

MGB/7980R

Type

Recombinant

Applications

IHC-P

Purity

Protein A/G affinity

Format

Purified

Buffer

0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide

Reconstitution

Aliquot the Mammaglobin antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Limitations

This Mammaglobin antibody is available for research use only.

Storage Conditions

Aliquot the Mammaglobin antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.

Formulation

0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide

Applications Notes

Optimal dilution of the Mammaglobin antibody should be determined by the researcher.

Location

Cytoplasm

Image Legend

IHC staining of FFPE human lactating breast tissue with Mammaglobin antibody (clone MGB/7980R) . HIER: boil tissue sections in pH 9 10mM Tris with 1mM EDTA for 20 min and allow to cool before testing.