ZNF488 Antibody
Zinc finger proteins contain DNA-binding domains and have a wide variety of functions, most of which encompass some form of transcriptional activation or repression. The majority of zinc finger proteins contain a Kruppel-type DNA binding domain and a KRAB domain, which is thought to interact with KAP1, thereby recruiting histone modifying proteins. ZNF488 is a 340 amino acid transcriptional regulator belonging to the Kruppel C2H2-type zinc finger protein family. ZNF488 localizes to the nucleus and contains two C2H2-type zinc fingers. ZNF488 is encoded by a gene located on chromosome 10, which contains a plethora of interesting genes and represents between 4 and 4.5 percent of the total DNA in cells. Jackson-Weiss, Cowden and Usher syndromes are a few diseases related to genes on chromosome 10.
Product Specifications
CAS Number
9007-83-4
Specifications
Flow cytometry: 1-2ug/million cells, Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
Q96MN9
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (within amino acids 170-307) from the human protein was used as the immunogen for the ZNF488 antibody.
Clonality
Monoclonal
Isotype
IgG2a
Clone
PCRP-ZNF488-2D8
Applications
FACS, IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the ZNF488 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This ZNF488 antibody is available for research use only.
Storage Conditions
Aliquot the ZNF488 antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the ZNF488 antibody should be determined by the researcher.
Location
Nucleus
Image Legend
Frequently Asked Questions
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