C-RET Antibody
The Ret proto-oncogene is structurally related to the growing family of tyrosine kinase transmembrane receptors and is involved in GDNF signaling. RET expression is reported in several regions of the central nervous system; in the developing cranial nerve ganglia and a subset of cells within dorsal root ganglia, in motor neurons in the spinal cord and hindbrain, in neuro-retina and the growing tips of the renal collecting ducts in developing kidney. Alterations in RET gene are associated with diseases including papillary thyroid carcinoma, multiple endocrine neoplasia (type 2A and 2B), familial medullary thyroid carcinoma, and a congenital developmental disorder known as Hirschsprung s disease.
Product Specifications
CAS Number
9007-83-4
Specifications
Immunohistochemistry (FFPE) : 1-2 µg/mL for 30 minutes at RT
UniProt
P07949
Host
Mouse
Reactivity
Human
Immunogen
A recombinant partial protein (within amino acids 702-848) from the human protein was used as the immunogen for the c-RET antibody.
Clonality
Monoclonal
Isotype
IgG2c κ
Clone
RET/8789
Applications
IHC-P
Purity
Protein A/G affinity
Format
Purified
Buffer
0.2 mg/ml in 1X PBS with 0.1 mg/ml BSA (US sourced), 0.05% sodium azide
Reconstitution
Aliquot the c-RET antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.
Limitations
This c-RET antibody is available for research use only.
Storage Conditions
Aliquot the c-RET antibody and store frozen at -20°C or colder. Avoid repeated freeze-thaw cycles.
Formulation
0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced), 0.05% sodium azide
Applications Notes
Optimal dilution of the c-RET antibody should be determined by the researcher.
Location
Cytoplasmic, nuclear, cell surface
Image Legend
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