MX1 Antibody / Myxovirus resistance protein 1 / MxA

Interferon-induced GTP-binding protein Mx1, also called Myxovirus resistance protein 1, Myxoma resistance protein 1 and MxA, is a protein that in humans is encoded by the MX1 gene. This gene encodes a guanosine triphosphate (GTP) -metabolizing protein that participates in the cellular antiviral response. The encoded protein is induced by type I and type II interferons and antagonizes the replication process of several different RNA and DNA viruses. There is a related gene located adjacent to this gene on chromosome 21, and there are multiple pseudogenes located in a cluster on chromosome 4. Alternative splicing results in multiple transcript variants.

Product Specifications

CAS Number

9007-83-4

Specifications

Western blot: 0.5-1 µg/mL, Flow cytometry: 1-3ug/million cells, Direct ELISA: 0.1-0.5 µg/mL

UniProt

P20591

Host

Rabbit

Reactivity

Human, Mouse

Immunogen

Recombinant human protein (amino acids K435-Q621) was used as the immunogen for the MX1 antibody.

Clonality

Polyclonal

Isotype

IgG

Applications

WB, FACS, Direct ELISA

Purity

Antigen affinity purified

Format

Antigen affinity purified

Buffer

Lyophilized from 1X PBS with 2% Trehalose

Reconstitution

After reconstitution, the MX1 antibody can be stored for up to one month at 4oC. For long-term, aliquot and store at -20oC. Avoid repeated freezing and thawing.

Limitations

This MX1 antibody is available for research use only.

Storage Conditions

After reconstitution, the MX1 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Formulation

0.5 mg/mL if reconstituted with 0.2ml sterile DI water

Applications Notes

Optimal dilution of the MX1 antibody should be determined by the researcher.

Image Legend

Flow cytometry testing of human RT4 cells with MX1 antibody at 1ug/million cells (blocked with goat sera) ; Red=cells alone, Green=isotype control, Blue= MX1 antibody.