ERLIN2 Antibody
Erlin-2 is a protein that in humans is encoded by the ERLIN2 gene. This gene encodes a member of the SPFH domain-containing family of lipid raft-associated proteins. The encoded protein is localized to lipid rafts of the endoplasmic reticulum and plays a critical role in inositol 1,4,5-trisphosphate (IP3) signaling by mediating ER-associated degradation of activated IP3 receptors. Mutations in this gene are a cause of spastic paraplegia-18 (SPG18) . Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Product Specifications
CAS Number
9007-83-4
Specifications
Western blot: 0.5-1 µg/mL, Immunohistochemistry (FFPE) : 2-5 µg/mL, Immunofluorescence: 5 µg/mL, Flow cytometry: 1-3ug/million cells
UniProt
O94905
Host
Mouse
Reactivity
Human
Immunogen
Recombinant human protein (amino acids D87-N339) was used as the immunogen for the ERLIN2 antibody.
Clonality
Monoclonal
Isotype
IgG2b
Clone
3H9A2
Applications
WB, IHC-P, IF, FACS
Purity
Antigen affinity purified
Format
Antigen affinity purified
Buffer
Lyophilized from 1X PBS with 2% Trehalose
Reconstitution
Limitations
This ERLIN2 antibody is available for research use only.
Storage Conditions
Formulation
0.5 mg/mL if reconstituted with 0.2ml sterile DI water
Applications Notes
Optimal dilution of the ERLIN2 antibody should be determined by the researcher.
Location
Cytoplasmic
Image Legend
IHC staining of FFPE human placental tissue with ERLIN2 antibody. HIER: boil tissue sections in pH8 EDTA for 20 min and allow to cool before testing.
Documents
Frequently Asked Questions
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