HDL-16
HDL-16 is a potent P2Y14R antagonist with an IC50 of 0.3095 nM. HDL-16 ameliorates DSS (HY-116282C) -induced colitis through suppressing necroptosis of intestinal epithelium cells (IECs) and protecting mucosal barrier function[1].
Product Specifications
CAS Number
[2373280-36-3]
UNSPSC
12352005
Target
Necroptosis; P2Y Receptor
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/hdl-16.html
Purity
99.19
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
BrC(C=C1)=CC=C1NCC2=NC3=CC=CC=C3O2
Molecular Formula
C14H11BrN2O
Molecular Weight
303.15
References & Citations
14
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
P2Y14 Receptor
Available Sizes
Curated Selection
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