SIRT5 inhibitor 1
SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM.
Product Specifications
CAS Number
[2166487-21-2]
UNSPSC
12352005
Hazard Statement
H301, H311, H331
Target
Sirtuin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/SIRT5_inhibitor.html
Purity
99.65
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
O=S(N[C@@H](CCCCNC(NCCC(O)=O)=S)C(N[C@H](C(NC1CCC1)=O)CC2=CNC3=CC=CC=C23)=O)(C4=CC(F)=CC=C4)=O
Molecular Formula
C31H39FN6O6S2
Molecular Weight
674.81
Precautions
H301, H311, H331
References & Citations
[1]Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56 (47) :14836-14841.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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