α-Terpineol

α-Terpineol (with oral activity) can be found in Eucalyptus globulus Labill. α-Terpineol exhibits strong antimicrobial activity against periodontopathic and cariogenic bacteria.α-Terpineol possesses antifungal activity against T. mentagrophytes, and the activity might lead to irreversible cellular disruption. In addition, α-Terpineol exhibits antineuropathic and anti-inflammatory activities. α-Terpineol can be utilized in research related to diarrhea, neuropathic pain, infections, and inflammation[1][2][3][4][5][6][7].

Product Specifications

CAS Number

[98-55-5]

UNSPSC

12352211

Hazard Statement

H227, H315, H319, H402

Target

AMPK; Antibiotic; Bacterial; Fungal; NF-κB

Type

Natural Products

Related Pathways

Anti-infection; Epigenetics; NF-κB; PI3K/Akt/mTOR

Applications

COVID-19-immunoregulation

Field of Research

Infection; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/alpha-terpineol.html

Purity

99.47

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

OC(C)(C)C1CC=C(C)CC1

Molecular Formula

C10H18O

Molecular Weight

154.25

Precautions

H227, H315, H319, H402

References & Citations

[1]Park SN, et al. Antimicrobial effect of linalool and α-terpineol against periodontopathic and cariogenic bacteria. Anaerobe. 2012 Jun;18 (3) :369-72.|[2]Park MJ, et al. Effect of citral, eugenol, nerolidol and alpha-terpineol on the ultrastructural changes of Trichophyton mentagrophytes. Fitoterapia. 2009 Jul;80 (5) :290-6.|[3]Held S, et al. Characterization of alpha-terpineol as an anti-inflammatory component of orange juice by in vitro studies using oral buccal cells. J Agric Food Chem. 2007 Oct 3;55 (20) :8040-6.|[4]Trinh HT, et al. Artemisia princeps Pamp. Essential oil and its constituents eucalyptol and α-terpineol ameliorate bacterial vaginosis and vulvovaginal candidiasis in mice by inhibiting bacterial growth and NF-κB activation. Planta Med. 2011 Dec;77 (18) :1996-2002.|[5]Dos Santos Negreiros P, et al. Antidiarrheal activity of α-terpineol in mice. Biomed Pharmacother. 2019 Feb;110:631-640.|[6]Bilbrey JA, et al. Evaluation of the terpenes β-caryophyllene, α-terpineol, and γ-terpinene in the mouse chronic constriction injury model of neuropathic pain: possible cannabinoid receptor involvement. Psychopharmacology (Berl) . 2022 May;239 (5) :1475-1486.|[7]Choi YJ, et al. α-Terpineol induces fatty liver in mice mediated by the AMP-activated kinase and sterol response element binding protein pathway. Food Chem Toxicol. 2013 May;55:129-36.