P-Ethynylphenylalanine (hydrochloride)
P-Ethynylphenylalanine hydrochloride (4-Ethynyl-L-phenylalanine hydrochloride) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1]. p-Ethynylphenylalanine (hydrochloride) is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
Product Specifications
CAS Number
[188640-63-3]
Product Name Alternative
4-Ethynyl-L-phenylalanine (hydrochloride)
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Tryptophan Hydroxylase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/4-ethynyl-l-phenylalanine-hydrochloride.html
Concentration
10mM
Purity
99.23
Solubility
DMSO : 50 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 12.5 mg/mL (ultrasonic)
Smiles
N[C@@H](CC1=CC=C(C#C)C=C1)C(O)=O.[H]Cl
Molecular Formula
C11H12ClNO2
Molecular Weight
225.67
Precautions
H302, H315, H319, H335
References & Citations
[1]Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74 (5) :2067-73.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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