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Bfl-1-IN-5

Bfl-1-IN-5 (Compound (R, R, S) -26) is a selective inhibitor for Bfl-1 with an IC50 of 0.022 μM. Bfl-1-IN-5 promotes the caspase-3/7 activity with an EC50 of 0.37 μM, and inhibits the cell viability of SU-DHL-1 with an EC50 of 1.3 μM[1].

Product Specifications

UNSPSC

12352005

Target

Bcl-2 Family; Caspase

Type

Reference compound

Related Pathways

Apoptosis

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/bfl-1-in-5.html

Smiles

C=CC(N(C1=CC=C(O[C@H]2C[C@H](N)CC2)C=C1)[C@H](C3=CC=C(C(F)(F)F)C(C#N)=C3)C)=O

Molecular Formula

C24H24F3N3O2

Molecular Weight

443.46

References & Citations

[1]Lucas SCC, et al., Structure-Based Optimization of a Series of Covalent, Cell Active Bfl-1 Inhibitors. J Med Chem. 2024 Sep 26;67 (18) :16455-16479.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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