Purotoxin-1

<strong>Purotoxin-1</strong> <strong>Catalog number:</strong> MDP0815 <strong>CAS Number: </strong>90092-07-2 <strong>Sequence: </strong>Gly-Tyr-Cys-Ala-Glu-Lys-Gly-Ile-Arg-Cys-Asp-Asp-Ile-His-Cys-Cys-Thr-Gly-Leu-Lys-Cys-Lys-Cys-Asn-Ala-Ser-Gly-Tyr-Asn-Cys-Val-Cys-Arg-Lys-Lys (Reported disulfide bonds between Cys3-Cys16, Cys10-Cys21, Cys15-Cys32, and Cys23-Cys30) <strong>Amount:</strong> 100 ug <strong>Molecular Weight:</strong> 3836.4 g/mol <strong>Supplied as:</strong> Powder <strong>Applications:</strong> molecular tool for various biochemical applications <strong>Storage:</strong> -20 °C <strong>WARNING:</strong> For in vitro Research Use Only. NOT for use on humans or animals. <strong>Grade:</strong> Biotechnology grade. All products are highly pure. <strong>References:</strong> 1: Servin-Garrido RR, Ilhuicatzi-Alvarado D, Jiménez-Chávez ÁJ, Moreno-Fierros L. Cry1Ac Protoxin Confers Antitumor Adjuvant Effect in a Triple-Negative Breast Cancer Mouse Model by Improving Tumor Immunity Breast Cancer (Auckl). 2022 Jan 5;16:11782234211065154. 2: Qi L, Qiu X, Yang S, Li R, Wu B, Cao X, He T, Ding X, Xia L, Sun Y. Cry1Ac Protoxin and Its Activated Toxin from Bacillus thuringiensis Act Differentially during the Pathogenic Process J Agric Food Chem. 2020 May 27;68(21):5816-5824. 3: Liao C, Jin M, Cheng Y, Yang Y, Soberón M, Bravo A, Liu K, Xiao Y. Bacillus thuringiensis Cry1Ac Protoxin and Activated Toxin Exert Differential Toxicity Due to a Synergistic Interplay of Cadherin with ABCC Transporters in the Cotton Bollworm Appl Environ Microbiol. 2022 Apr 12;88(7):e0250521. 4: Rukmini V, Reddy CY, Venkateswerlu G. Bacillus thuringiensis crystal delta-endotoxin: role of proteases in the conversion of protoxin to toxin Biochimie. 2000 Feb;82(2):109-16. 5: Guo Z, Gong L, Kang S, Zhou J, Sun D, Qin J, Guo L, Zhu L, Bai Y, Bravo A, Soberón M, Zhang Y. Comprehensive analysis of Cry1Ac protoxin activation mediated by midgut proteases in susceptible and resistant Plutella xylostella (L.) Pestic Biochem Physiol. 2020 Feb;163:23-30. 6: Yang J, Chen S, Xu X, Lin G, Lin S, Bai J, Song Q, You M, Xie M. Novel-miR-310 mediated response mechanism to Cry1Ac protoxin in Plutella xylostella (L.) Int J Biol Macromol. 2022 Oct 31;219:587-596. 7: Xu H, Li T, Rohou A, Arthur CP, Tzakoniati F, Wong E, Estevez A, Kugel C, Franke Y, Chen J, Ciferri C, Hackos DH, Koth CM, Payandeh J. Structural Basis of Nav1.7 Inhibition by a Gating-Modifier Spider Toxin Cell. 2019 Feb 7;176(4):702-715.e14. 8: Wei J, Liang G, Wang B, Zhong F, Chen L, Khaing MM, Zhang J, Guo Y, Wu K, Tabashnik BE. Activation of Bt Protoxin Cry1Ac in Resistant and Susceptible Cotton Bollworm PLoS One. 2016 Jun 3;11(6):e0156560. 9: Li X, Zhao F, Qiu X, Ren X, Mo X, Ding X, Xia L, Sun Y. The full-length Cry1Ac protoxin without proteolytic activation exhibits toxicity against insect cell line CF-203 J Invertebr Pathol. 2018 Feb;152:25-29. <a href="https://pubmed.ncbi.nlm.nih.gov/33742442">10: Montnach J, De Waard S, Nicolas S, Burel S, Osorio N, Zoukimian C, Mantegazza M, Boukaiba R, Béroud R, Partiseti M, Delmas P, Marionneau C, De Waard M. Fluorescent- and tagged-protoxin II peptides: potent markers of the Na(v) 1.7 channel pain target Br J Pharmacol. 2021 Jul;178(13):2632-2650. </a> <br><strong>Products Related to Purotoxin-1 can be found at</strong> <a href="https://moleculardepot.com/product-category/Peptides/"> Peptides</a>