Conoidin A
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) [1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].
Product Specifications
CAS Number
18080-67-6
UNSPSC
12352005
Hazard Statement
H302, H314
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/conoidin-a.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
[O-][N+]1=C(C(CBr)=[N+](C2=C1C=CC=C2)[O-])CBr
Molecular Formula
C10H8Br2N2O2
Molecular Weight
347.99
Precautions
H302, H314
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Toxoplasma
Available Sizes
Frequently Asked Questions
Explore Other Products
Browse additional items from our catalog
Recombinant Escherichia coli Imidazole glycerol phosphate synthase subunit HisH (hisH)
Recombinant Escherichia coli Imidazole glycerol phosphate synthase subunit HisH (hisH)
Recombinant Escherichia coli Imidazole glycerol phosphate synthase subunit HisH (hisH)
Recombinant Escherichia coli Imidazole glycerol phosphate synthase subunit HisH (hisH)
Recombinant Escherichia coli Imidazole glycerol phosphate synthase subunit HisH (hisH)