Conoidin A
Conoidin A is a cell permeable inhibitor of T. gondii enzyme peroxiredoxin II (TgPrxII) with nematicidal properties. Conoidin A covalently binds to the peroxidatic Cys47 of TgPrxII, irreversibly inhibiting its hyperperoxidation activity with an IC50 of 23 μM. Conoidin A also inhibits hyperoxidation of mammalian PrxI and PrxII (but not PrxIII) [1][2]. Conoidin A has antioxidant, neuroprotective effects and can be used for the research of ischaemic heart disease[3].
Product Specifications
CAS Number
18080-67-6
UNSPSC
12352005
Hazard Statement
H302, H314
Target
Parasite
Type
Reference compound
Related Pathways
Anti-infection
Applications
COVID-19-immunoregulation
Field of Research
Infection; Neurological Disease; Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/conoidin-a.html
Concentration
10mM
Purity
99.32
Solubility
DMSO : 14.29 mg/mL (ultrasonic)
Smiles
[O-][N+]1=C(C(CBr)=[N+](C2=C1C=CC=C2)[O-])CBr
Molecular Formula
C10H8Br2N2O2
Molecular Weight
347.99
Precautions
H302, H314
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Toxoplasma
Available Sizes
Frequently Asked Questions
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