Batoprotafib
Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 µM) . Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].
Product Specifications
CAS Number
1801765-04-7
Product Name Alternative
TNO155
UNSPSC
12352005
Hazard Statement
H315, H319, H320
Target
Phosphatase; SHP2
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/batoprotafib.html
Purity
99.41
Solubility
DMSO : 66.67 mg/mL (ultrasonic)
Smiles
N[C@@H]1[C@H](C)OCC12CCN(C3=NC(N)=C(SC4=C(Cl)C(N)=NC=C4)N=C3)CC2
Molecular Formula
C18H24ClN7OS
Molecular Weight
421.95
Precautions
H315, H319, H320
References & Citations
[1]TNO155: SHP2 inhibitor|[2]Liu C, et al. Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling. Clin Cancer Res. 2021 Jan 1;27 (1) :342-354.|[3]Weiss A, et al. Discovery, Preclinical Characterization, and Early Clinical Activity of JDQ443, a Structurally Novel, Potent, and Selective Covalent Oral Inhibitor of KRASG12C. Cancer Discov. 2022 Jun 2;12 (6) :1500-1517.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 2
Available Sizes
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
BNC042349-100 1x 100 µL
MUC16 / CA125 (Ovarian Carcinoma Marker) (OCA125/2349R), CF405S conjugate, 0.1mg/mL
Sign In for Pricing
View Details ![STAT5B Rabbit Monoclonal Antibody [Clone ID: R01-6A3]](https://cdn.genprice.uk/products/937/6868c2cf994c49e6dc3e79f7/imageurl/ta385339.webp)
TA385339 100 µL
STAT5B Rabbit Monoclonal Antibody [Clone ID: R01-6A3]
Sign In for Pricing
View Details ![NEDD4 Mouse Monoclonal Antibody [Clone ID: OTI5A8]](https://cdn.genprice.uk/products/937/68dd18bb061270361e908dcd/imageurl/cf812642.webp)
13504-AAT 100 Tests
Amplite® Fluorimetric Caspase 3/7 Assay Kit *Red Fluorescence*
Sign In for Pricing
View Details 
TRC-D194295-100MG 100 mg
Pentaerythritol Tris Ester With 3-(3,5-Di-tert-butyl-4-hydroxyphenyl)propionic Acid
Sign In for Pricing
View Details