Fmoc-Val-Ala-PAB-OH
Fmoc-Val-Ala-PAB-OH is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
[1394238-91-5]
UNSPSC
12352203
Hazard Statement
H302, H315, H319, H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fmoc-val-ala-pab-oh.html
Purity
99.88
Solubility
DMSO : 31.25 mg/mL (ultrasonic)
Smiles
OCC(C=C1)=CC=C1NC([C@H](C)NC([C@H](C(C)C)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=O)=O
Molecular Formula
C30H33N3O5
Molecular Weight
515.60
Precautions
H302, H315, H319, H335
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C (Powder, stored under nitrogen)
Scientific Category
ADC Related
Clinical Information
Phase 1
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
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