JLB2-110c
Product Specifications
UNSPSC Description
JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect[1].
Target Antigen
Melanocortin Receptor
Type
Peptides
Related Pathways
GPCR/G Protein;Neuronal Signaling
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Endocrinology; Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/jlb2-110c.html
Solubility
10 mM in DMSO
Smiles
CC(N[C@H](C(N[C@H](C(N[C@H](C(NCCCC[C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H]3CCCN3C1=O)=O)=O)CC4=CNC=N4)=O)CC5=CC=CC=C5)=O)CCCNC(N)=N)=O)CC6=CNC7=C6C=CC=C7)=O)CN)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O
Molecular Weight
1545.80
References & Citations
[1]Ericson MD, et al. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys(Arg-Arg-Arg-Ac)-DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro)]. ACS Pharmacol Transl Sci. 2024 Apr 2;7(4):1114-1125.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-P6176/JLB2-110c-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-P6176/
Clinical Information
No Development Reported
CAS Number
3032608-72-0
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