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JLB2-110c

JLB2-110c activates MCRs receptor (mMC4R EC50 = 0.34 nM) and has a strong in vivo appetite suppressant effect[1].

Product Specifications

CAS Number

3032608-72-0

UNSPSC

12352209

Target

Melanocortin Receptor

Type

Peptides

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/jlb2-110c.html

Solubility

10 mM in DMSO

Smiles

CC(N[C@H](C(N[C@H](C(N[C@H](C(NCCCC[C@@H]1NC([C@@H](NC([C@@H](NC([C@@H](NC([C@H](NC([C@@H](NC([C@@H]2CCCN2C([C@H]3CCCN3C1=O)=O)=O)CC4=CNC=N4)=O)CC5=CC=CC=C5)=O)CCCNC(N)=N)=O)CC6=CNC7=C6C=CC=C7)=O)CN)=O)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CCCNC(N)=N)=O

Molecular Formula

C71H108N28O12

Molecular Weight

1545.80

References & Citations

[1]Ericson MD, et al. Incorporation of Three Extracyclic Arginine Residues into a Melanocortin Macrocyclic Agonist (c[Pro-His-DPhe-Arg-Trp-Dap-Lys (Arg-Arg-Arg-Ac) -DPro]) Decreases Food Intake When Administered Intrathecally or Subcutaneously Compared to a Macrocyclic Ligand Lacking Extracyclic Arginine Residues (c[Pro-His-DPhe-Arg-Trp-Dap-Ala-DPro) ]. ACS Pharmacol Transl Sci. 2024 Apr 2;7 (4) :1114-1125.

Shipping Conditions

Room temperature

Scientific Category

Peptides

Clinical Information

No Development Reported

Frequently Asked Questions

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