FXIIIa-IN-1
FXIIIa-IN-1 (Compound 16) is a potent and selective FXIIIa (Factor XIIIa) inhibitor with an IC50 value of 2.4 μM. FXIIIa-IN-1 inhibits FXIIIa by competing with the Gln-donor protein substrate (dimethylcasein) . FXIIIa-IN-1 holds promise for the development of effective and safe novel anticoagulants[1].
Product Specifications
CAS Number
55909-92-7
UNSPSC
12352005
Target
Factor VIII
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/fxiiia-in-1.html
Smiles
NC1=C2C(O)=C(/N=N/C3=CC=C(S(=O)(CCOS(=O)(O)=O)=O)C=C3)C(S(=O)(O)=O)=CC2=CC(S(=O)(O)=O)=C1/N=N/C4=CC=C(S(=O)(CCOS(=O)(O)=O)=O)C=C4
Molecular Formula
C26H25N5O19S6
Molecular Weight
903.89
References & Citations
[1]Vu KT, et al. Discovery of Heparin Mimetic, Potent, and Selective Inhibitors of Human Clotting Factor XIIIa. ACS Omega. 2024 Jul 3;9 (28) :31105-31119.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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