Dencatistat

Dencatistat (P115) is an inhibitor of Cytidine Triphosphate Synthase 1 (CTPS1) with an IC50 value of ≤ 0.1 μM. Dencatistat can be used for research on cancer (such as leukemia and lymphoma), inflammatory skin diseases (such as psoriasis), or multiple sclerosis[1].

Product Specifications

CAS Number

[2377000-84-3]

UNSPSC

12352005

Target

DNA/RNA Synthesis

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage

Applications

COVID-19-anti-virus

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ctps1-in-2.html

Purity

99.04

Solubility

DMSO : 12.5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(C1(CCOCC1)C2=NC(NS(=O)(C3CC3)=O)=NC=C2)NC4=NC=C(C5=CN=CC(OCC)=N5)C=C4

Molecular Formula

C24H27N7O5S

Molecular Weight

525.58

References & Citations

[1]Quddus, et al. "N- (4- (5-chloropyridin-3-yl) phenyl) -2- (2- (cyclopropanesulfonamido) pyrimidin-4-yl) butanamide derivatives and related compounds as human CTPS1 inhibitors for the treatment of proliferative diseases." U.S. Patent. WO2019179652 A1. 2023-03-23