PPL agonist-1
Product Specifications
UNSPSC Description
PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment[1].
Target Antigen
Microtubule/Tubulin; Tyrosinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Cytoskeleton;Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ppl-agonist-1.html
Smiles
CC1=C(F)C=CC(C2=CC=C([C@@H](NC3=NC(NS(=O)(C4=CC([N+]([O-])=O)=CC=C4)=O)=CC=N3)C)C=C2)=C1
Molecular Weight
507.54
References & Citations
[1]Zhong H, Li P, Yan Q, Xia Y, Zhang X, Lai Y, Li L, Wang F, Shang J, Zha X. Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo. J Med Chem. 2024 Nov 14;67(21):19323-19341.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-159917/PPL-agonist-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-159917/
Clinical Information
No Development Reported
CAS Number
3040997-52-9
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