PPL agonist-1

PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment[1].

Product Specifications

CAS Number

[3040997-52-9]

UNSPSC

12352005

Target

Microtubule/Tubulin; Tyrosinase

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease

Field of Research

Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/ppl-agonist-1.html

Smiles

CC1=C(F)C=CC(C2=CC=C([C@@H](NC3=NC(NS(=O)(C4=CC([N+]([O-])=O)=CC=C4)=O)=CC=N3)C)C=C2)=C1

Molecular Formula

C25H22FN5O4S

Molecular Weight

507.54

References & Citations

[1]Zhong H, Li P, Yan Q, Xia Y, Zhang X, Lai Y, Li L, Wang F, Shang J, Zha X. Targeting Periplakin of Novel Benzenesulfonamides as Highly Selective Agonists for the Treatment of Vitiligo. J Med Chem. 2024 Nov 14;67 (21) :19323-19341.