PPL agonist-1
PPL agonist-1 is a highly selective Periplakin (PPL) agonist that increases cAMP levels by regulating PPL, thereby enhancing MITF expression and promoting melanin synthesis. Furthermore, PPL agonist-1 facilitates melanin production by regulating tryptophan metabolism. Compared to Ruxolitinib (HY-50856), PPL agonist-1 demonstrates superior efficacy. PPL agonist-1 holds potential for research into vitiligo treatment[1].
Product Specifications
CAS Number
[3040997-52-9]
UNSPSC
12352005
Target
Microtubule/Tubulin; Tyrosinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton; Metabolic Enzyme/Protease
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/ppl-agonist-1.html
Smiles
CC1=C(F)C=CC(C2=CC=C([C@@H](NC3=NC(NS(=O)(C4=CC([N+]([O-])=O)=CC=C4)=O)=CC=N3)C)C=C2)=C1
Molecular Formula
C25H22FN5O4S
Molecular Weight
507.54
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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RUVBL2 (RuvB-like 2, RVB2, 48kD TATA Box-binding Protein-interacting Protein, 48kD TBP-interacting Protein, TIP48, 51kD Erythrocyte Cytosolic Protein, ECP51, ECP-51, CGI-46, INO80 Complex Subunit J, INO80J, Repressing Pontin 52, Reptin 52, TIP49b, TIP60-a